6/27/2023 0 Comments Exon and intron using macvector![]() Drosophila melanogaster is predicted to have a complex RFeSP locus encoding at least two different proteins by an alternative intron-retention mechanism, according to published reference sequences 11, 12, 13, 14 ( Fig. Rieske iron sulphur proteins (RFeSPs) are essential, highly conserved functional constituents of energy-transducing respiratory complexes 10. This work also allows us to test whether any de novo gene origination would arise as a consequence of non-adaptive mechanisms by the stochastic accumulation of neutral or quasi-neutral mutations. Fortunately, decades of theoretical work on the neutral theories of evolution as a null hypothesis for molecular evolution 6, 7, 8, 9 have provided a solid theoretical framework for understanding gene origination. Random genetic drift, population bottlenecks, genetic sweeps and the extinction of species are a few of the natural processes that affect the frequency of transitional alleles and commonly contribute to a discontinuous mutational lineage through time. This might be because, despite recent advances in genome sequencing, it remains a challenge to reconstruct with confidence the evolutionary pathway of the origination of any novel coding region 1, 2, 3, 4, 5. ![]() However, the processes, or constraints, that lead to the origin of novel coding regions have seldom been studied systematically. Natural selection and neutral drift have been postulated to shape de novo coding sequences following their assembly from non-coding DNA 1, 2, 3.
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